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MAIN GOALS IN MIGRAINE TREATMENT

19 Temmuz 2023/0 Yorumlar/in migren/tarafından drturan_pyrzawp

If we had to use one word to describe our approach to successful migraine treatment, it would be “balance.”

What Do You Want to Know About Migraines?

Most people who suffer from migraines are unhappy with their current treatment options, which are ineffective and often have negative side effects. Our main goal in Migraine Treatment is to work to balance steroid hormones, especially pregnenolone, DHEA, estrogen, progesterone, and testosterone; reset pineal gland function using melatonin and other natural substances; improve gastrointestinal and digestive health with probiotics; and work to restore the balance between calcium and magnesium, two minerals that play a crucial role in migraines.

In addition to eliminating migraines and their associated symptoms, Migraine Cure has been shown to relieve other conditions that often accompany migraines, including high cholesterol, heart disease, and fibromyalgia.

Migraine Treatment

One of the important steps for “Migraine Treatment” is to balance the function of certain systems in the body, and to adapt the doses of certain hormones and other natural substances to meet the different needs of each individual.
The successful treatment approach for migraine involves a regulated and synchronized adjustment of various systems and functions in the body to achieve this goal. These areas are as follows:
Neurohormonal system: It includes the activities of the hypothalamus, pituitary gland and steroid hormones, namely the ovaries, testicles and adrenal glands. Our goal is to balance the hormones produced by these glands.

Pineal gland: This gland balances the cyclical production of serotonin and melatonin hormones, both key players in migraine. Therefore, our goal is to reset the function of the pineal gland.
Digestive system: 70% of migraine sufferers have problems in the digestive system, and restoring the balance within the digestive system is a critical part of Migraine Treatment.
Magnesium balance: Another factor is to maintain a balance between two critical minerals, magnesium and calcium, as an imbalance between these substances is a very important factor in migraine.

Sympathetic and parasympathetic systems: While working to balance the four systems mentioned above, a balance should also be worked on between the sympathetic and parasympathetic nervous systems, which is the ultimate goal of Migraine Treatment.

A detailed assessment of your current hormonal status is needed to start the treatment correctly.

Tests you will need: Blood Tests You Need

Lipid panel (total cholesterol, LDL, HDL and triglyceride)

Estrogen (women)
Estradiol (men)
Progesterone
Testosterone
DHEA-S,
Pregnenolone
Cortisol

Neurohormonal System

For women who are still menstruating, who make up the majority of migraine sufferers, the best time to test is between days 19 and 21 of the menstrual cycle, as this is when progesterone levels are at their highest.

While optimal hormone levels are critical, hormone balance is also important. Therefore, instead of measuring hormones by numbers, Migraine Therapy works to achieve a balanced ratio between complementary hormones such as estrogen and progesterone, as well as cortisol and DHEA. When you balance these hormones and achieve a hormonal balance specific to your unique body chemistry and needs, you can manage your migraines.

Cholesterol: The First Ingredient

Hormone production begins with cholesterol. Therefore, having healthy cholesterol levels is critical for adequate hormone production. Cholesterol levels that are too high or too low are insufficient for balancing hormone levels. Therefore, when starting treatment for people with migraine, we look at a lipid panel (cholesterol, LDL, HDL, and triglycerides) along with a hormone panel.

Pregnenolone

Pregnenolone is not only the most prevalent hormone in the brain, but is also considered a “grandmother” hormone to all steroid hormones, including aldosterone, cortisol, cortisone, DHEA, estrogen, progesterone, and testosterone. (The term “steroid hormone” refers to a family of structurally similar biochemicals that have the ability to determine sex, reduce inflammation, and regulate growth.)

Therefore, when levels of any of these hormones fall below normal, pregnenolone levels are typically affected.
Here are some of the properties attributed to pregnenolone and some of the reasons why it is such an important hormone in the fight against migraines:
It has the ability to normalize levels of other hormones.
It helps in the formation of new brain cells and therefore has a positive effect on learning, concentration and memory.
It improves mood and relieves depressive symptoms.
It improves inflammation and allergies.
It improves premenstrual syndrome and menopausal symptoms.

Pregnenolone is considered safe even in high doses. However, since pregnenolone is converted to DHEA and then progesterone, it is recommended to have periodic blood tests of hormones, as we did in the Migraine Cure.

DHEA

While pregnenolone is the grandmother of hormones and the precursor to dehydroepiandrosterone (DHEA), DHEA is the mother, as it is a precursor to estrogens and testosterone.

While low DHEA levels are associated with aging, they are also associated with, but are not limited to, migraines, chronic inflammation, depression, rheumatoid arthritis, memory and concentration difficulties, osteoporosis, heart disease (in men), complications of Type II diabetes, and an increased risk of certain cancers. One of DHEA’s main functions is to suppress the damaging properties of stress. Maintaining an optimal DHEA/cortisol ratio is not only critical to preventing aging, but is also important in managing migraines.

Your body’s DHEA production can be determined by measuring the amount of DHEA-sulfate (DHEA-S) in a blood sample. Since DHEA is a precursor to estrogens and testosterone, it can have some effects on the levels of these hormones. We recommend that individuals take 7-keto DHEA; 7-keto DHEA is a product of DHEA metabolism. The most important feature of 7-keto is that, unlike DHEA, it does not convert into estrogen and testosterone.

Estrogen and Progesterone

Estrogen and progesterone are naturally produced by the body and are typically thought of as female sex hormones. In fact, these two hormones are typically higher in women than in men, but both estrogen and progesterone are found in both sexes and in people of all ages. The roles of estrogen and progesterone in migraine are both critical and complex. We can group these two hormones together because they are so closely linked. It is the balance between them, not the restoration of optimal levels individually, that is critical for the relief of migraine, as well as the symptoms experienced by women during perimenopause and menopause.

Estrogen and Migraine

The relationship between estrogen levels and the development and elimination of migraines is an intimate one. Here’s what we know about estrogen and migraines:
Migraine prevalence increases at menarche (when a woman’s menstrual cycle first begins). A drop in estrogen levels just before menstruation triggers migraines in many women.
Migraines usually subside in the second and third trimesters of pregnancy, when estrogen levels are high.
Migraines usually become apparent soon after a woman gives birth, as they occur when estrogen levels drop significantly.

Testosterone

Testosterone is typically a male hormone, responsible for the normal development of the male sex and reproductive organs, and the development of secondary male sex characteristics and other characteristics, including hair growth (and loss), vocal cord thickening, and muscle development. Normal testosterone levels are necessary for maintaining healthy mood, energy levels, bone marrow production, fertility, and sexual desire. Women also need testosterone; their levels do not need to be as high as men’s, but optimal levels should be sufficient to maintain health. Testosterone levels need to be balanced in both men and women to eliminate migraines. In women, DHEA levels can be converted to testosterone when the body detects that testosterone levels are low. Therefore, careful use of DHEA (a precursor to testosterone) can help some women reach optimal levels, while others need testosterone supplements, at least temporarily.

Pineal Gland
Melatonin

Research findings support the idea that pineal dysregulation, and therefore melatonin imbalance, plays a role in the development of migraines. Melatonin is an important piece in the puzzle of migraine and sleep disorders. Balanced pineal gland function and healthy sleep patterns are critical components of a Migraine Treatment program.

Melatonin supplements are widely available in grocery stores, pharmacies, and online. A combination product containing melatonin, vitamin B6, or L theanine, taken one or two capsules at bedtime, may be recommended as part of the pineal for migraine treatment segment.

In most cases, patients only need to take melatonin for a few months until their circadian cycle is restored.

Additional Benefits of Migraine Treatment

Migraine Treatment not only eliminates migraines, it also helps people relieve many other symptoms and conditions. Most people living with migraines struggle with one or more health issues, including depression, insomnia, high cholesterol, constipation, irritable bowel syndrome, chronic fatigue, fibromyalgia, mood swings, menstrual difficulties, or sleep disorders. Therefore, in addition to hormone regulation, pineal gland balancing, calcium-magnesium rebalancing, digestion regulation, patients should know that other health issues will also be eliminated.

Vitamin B6

Vitamin B6 (pyridoxine) is an important part of a migraine treatment program for several reasons. When it comes to improving pineal function, vitamin B6 is needed for the production of serotonin, a brain neurotransmitter that plays an important role in sleep-wake cycles, chronic pain, mood, and appetite. Vitamin B6 has a calming effect.

Ensuring Digestive System Balance

The connection between migraine and the digestive system, especially the intestines, has been confirmed by numerous studies and clinical observations. When we question 60-70% of migraine patients, we encounter constipation or similar intestinal problems. Successful treatment of migraine depends on a healthy intestine. One of the most important things you can do to ensure a healthy intestinal tract is to maintain the balance between friendly and unfriendly bacteria in the intestinal flora. Friendly bacteria provide health-promoting or health-protecting properties, while unfriendly bacteria can significantly harm your health. When the balance tips in favor of bad bacteria, the intestines become damaged and inflamed. This condition, usually called dysbiosis, is characterized by symptoms such as diarrhea, constipation, gas, abdominal pain, cramping and bloating. If you have migraine, digestive system problems such as diarrhea, constipation, irritable bowel or abdominal pain, you need to balance your intestinal flora. You can use probiotics, which are necessary for your intestinal health, as supplements.

Probiotics

Probiotics are live, friendly bacteria that you can take to improve or restore the balance of the bacterial flora in your intestinal tract. The most common and essential friendly bacteria are bifidobacteria, streptococci, and lactobacilli, which perform many functions essential for good health.

They help absorb nutrients into your bloodstream. They form a barrier against harmful bacteria that can cause diarrhea. They produce food for your intestinal cells so they can function at their best. They help prevent harmful bacteria from causing damage.

They prevent symptoms caused by antibiotics, which can destroy many of the friendly bacteria in your intestinal tract.
After much research and experimentation, our recommended probiotic supplement is a powdered formula that contains 3.5 billion lactobacilli, 1 billion bifidobacteria, and 0.5 billion streptococci thermophila per dose. It is well tolerated and easy to use. After several months of taking this supplement daily, most people will find that occasional use, perhaps once a month, is sufficient for a healthy gut and overall health.

Magnesium balance
Migraine Cure is the restoration of the balance between two minerals critical to headache, ionized magnesium and ionized calcium. The balance between these two elements is closely linked to the activity of steroid hormones, the function of the pineal gland, the proper functioning of the digestive system, and also the balance between the sympathetic and parasympathetic nervous systems.

Calcium-Magnesium Ratio
The relationship between the calcium/magnesium ratio and migraine has been known for some time. For example, in 1993, researchers noted that low levels of ionized magnesium and high levels of ionized calcium were associated with migraine, and that both conditions caused cerebral vasospasm and reduced blood flow to the brain. A balanced calcium/magnesium ratio is also necessary to help prevent fatigue, which is common among migraineurs, and to regulate the sleep cycle. Again, this balance also reflects the balance between the sympathetic nervous system (which affects calcium) and the parasympathetic nervous system (which affects magnesium).

Magnesium

If magnesium deficiency is part of your migraine diagnosis, supplemental magnesium may be helpful. Several studies have shown that magnesium supplementation reduces migraine attacks in people with low serum ionized magnesium levels. We also know that magnesium supplementation can help with premenopausal symptoms, including migraines, bloating, and edema.

Although magnesium supplements come in a variety of forms and types (such as magnesium sulfate, oxide, gluconate, carbonate, and chloride), the form we recommend at Migraine Cure is magnesium citrate or magnesium malate. This is the type that the body absorbs best. It is a powdered, water-soluble magnesium supplement, 400-800 mg at bedtime, depending on individual needs. If you have any heart or kidney disease, be sure to talk to your doctor before taking magnesium.

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SPECIAL CIRCUMSTANCES AND MIGRAINE

19 Temmuz 2023/0 Yorumlar/in Genel/tarafından drturan_pyrzawp

Migraine during pregnancy

Women with migraine may experience migraine attacks more frequently in the first 3 months of their pregnancy due to hormonal changes that occur during the normal course of pregnancy. They experience fewer headaches in the second and third trimesters. This is because after the first 3 months, migraine attacks decrease due to reasons such as estrogen levels becoming stable, increasing endorphin levels, blood glucose metabolism becoming more regular, and muscle relaxation. All headaches experienced during pregnancy and breastfeeding should be taken seriously and should definitely be evaluated by a neurologist. Not all of these pains may be migraines and may be caused by an important underlying condition.

Especially the first headache or migraine attack experienced during pregnancy is a very important and important type of pain that should be paid attention to. The changing metabolism with pregnancy, changes in vascular circulation and hormonal status can trigger a number of serious diseases that can cause headaches. Unresponsiveness to treatment in migraine headaches during pregnancy requires investigating secondary causes. Of these, it is necessary to consider conditions such as preeclampsia and eclampsia, as well as diseases that can lead to thrombosis in the cerebral veins and threaten the life of the mother and the baby. In 10% of cases, the first migraine attack occurs during pregnancy.

Migraine attacks, which generally decrease in the last 6 months of pregnancy, may return with increasing frequency after birth due to reasons such as a sudden decrease in estrogen levels, changes in sleep patterns, and deterioration in quality of life. In addition, starting breastfeeding during this period may reduce the number of treatment options.

Therefore, in the treatment of migraine attacks that occur in the period immediately after pregnancy, it is necessary to take measures that increase the quality of life first and to be careful about sleep, nutrition, and migraine triggers. The possibility of simple painkillers and migraine-specific painkillers to be taken during headache attacks passing into the milk should be considered. For these reasons, milk should be expressed according to the time the drugs pass into the milk. In addition, the possibility of the passage of preventive treatments used in the classical sense into the milk should not be forgotten.

How is migraine pain treated during pregnancy?

Pregnancy plans should definitely be discussed with patients and the treatment they are receiving should be planned to be discontinued accordingly. If there is a pregnancy plan, the drugs that are dangerous to use during pregnancy should be reduced and discontinued according to a certain plan, and the treatment should be continued with the safest methods with strategies to be determined according to the patient’s condition. Attention should be paid to the risk groups of the drugs used here. In addition, sleep disorders, eating habits and other triggers that may increase migraine attacks should be determined. Since many drugs used in migraine treatment are not safe to use during pregnancy, it is the most rational approach for women with migraine who are planning a pregnancy to consult a neurologist before getting pregnant. Options for the treatment of migraine pain during pregnancy are limited. The best option is to carry out the treatment process together with your physician. Again, staying away from possible triggers, relaxation exercises, some biofeedback methods, meditation, yoga and maintaining regular healthy living habits form the basis of the pain method. However, despite these, some treatments can be recommended for pregnant women with migraine who have pain.

These;

Magnesium

The FDA has a safety category of D for pregnancy. In other words, its safety should be decided by considering the benefits it will provide to the patient.

Ondansetron

It is frequently used to prevent nausea and vomiting during pregnancy. It is pregnancy category B, and care should be taken when using it.

Metclopramide

It is used to treat nausea and vomiting during pregnancy. It is pregnancy category B. Central nervous system side effects should be taken into consideration.

Butalbital

This barbiturate derivative used in the treatment of headaches together with acetaminophen, aspirin, caffeine and codeine is prescribed quite frequently.

Paracetamol

It is a pregnancy category B drug used by most patients with pregnancy migraine. There is data that it may be associated with attention deficit hyperactivity in children.

Peripheral nerve blockade

It is a very reliable treatment method used for pregnancy migraine. It can usually be used comfortably after the 15th week of pregnancy and is quite effective.

Catamagnetic/Menstrual migraine

Menstrual migraine is more severe than migraine attacks seen in other periods and is also more resistant to treatment. The menstrual period is an important trigger, especially for migraines without aura. Due to hormonal changes, it occurs most frequently two days before menstruation and on the first day of menstruation. Correctly diagnosing menstrual migraine is important for determining the treatment strategy. In order to call migraine attacks related to menstruation, there must be migraine attacks without aura in at least two of the three menstrual periods, 2 days before and 3 days after menstruation. For this purpose, a headache diary should be kept for at least 3 months, the relationship between migraine attacks and menstruation should be clearly determined and the treatment strategy should be planned accordingly.

TREATMENT OF MENSTRUATION MIGRAINE

Non-drug Measures

In menstrual migraine, as in other migraine attacks, it is necessary to take measures to reduce attacks. It is necessary to pay attention to sleep patterns, stay away from foods that trigger migraine attacks and alcohol consumption, and avoid bright lights and strong odors. It is especially necessary to be careful about birth control drugs and hormone use.

Attack Treatment

Similar drugs are used for migraine attacks that occur during menstruation. Simple painkillers or migraine-specific painkillers (triptans) used during this period should be taken as soon as possible after the attack starts, depending on the severity of the attack.

These are treatments that are started 2 days before the menstrual period and continued for the first 3 days of the menstrual period. Since the start date of menstruation is important in this treatment plan, it can only be considered in women with regular menstrual periods. In cases of irregular menstrual periods, the date of starting the medication can be determined by measuring daily body temperature. While drugs used in migraine attack treatment can be used, drugs in the form of skin patches and gels can be used to control estrogen fluctuations.

Long-Term Preventive Treatment

In the long-term preventive treatment of menstrual migraine, hormone treatments can be used in addition to the classical drugs used for the preventive treatment of migraine. For this purpose, drugs containing estrogen in different doses, which can be applied orally or through the skin, can be used. Although less frequent, intrauterine progesterone applications can also be preferred. The aim of continuous hormonal treatment is to suppress the activity of the eggs and create a regular hormonal balance. However, it should not be forgotten that hormone treatment increases the risk of cerebrovascular disease, especially in those with migraine with aura, smokers, older people and those with risk factors.

Migraine in the perimenopausal period

The perimenopausal period is a period when there is a risk of migraine attacks becoming more frequent, along with many complications due to irregular menstrual periods. Vasomotor symptoms that can be observed during this period can be prevented with hormone replacement therapy. Oral estrogen preparations can trigger migraine attacks, therefore non-oral treatments are recommended for these symptoms. Intrauterine levonorgestrel may be a treatment option. In women in whom estrogen use is contraindicated, paroxetine 7.5 mg (at night) or gabapentin can be used to prevent vasomotor symptoms.

Migraine in the Elderly

Primary headaches decrease with age, and secondary headaches should be excluded in differential diagnosis. Very rarely, migraine headaches may occur after the age of 50. A distinction should be made between aura and transient ischemic attacks. Ergotamine and triptans should be avoided in patients with these symptoms or in patients at risk of ischemic attacks. Since the possibility of comorbidity is high in this age group, this situation should be taken into consideration in attack treatment and preventive treatment. Paracetamol, NSAI, combined analgesics, antiemetic agents, IV magnesium sulfate (2 gr, given over 10 minutes) can be used in attack treatment. Beta blockers, calcium channel blockers, antiepileptics, antidepressants can be used in preventive treatment.

Status Migraine

Status migraine is the attack lasting longer than 72 hours. The most important difference from chronic migraine is the duration (it is not a pain that lasts for 3 months like chronic migraine), the severity of the pain and accompanying symptoms. Secondary causes must be ruled out. Some patients need to be hospitalized and treated.

Childhood Migraine

The prevalence of migraine in children is around 10% for girls and 5% for boys. Childhood migraine headaches do not have typical features like those in adults. Children under the age of 12 may have difficulty defining their headaches, and typical symptoms such as photophobia and phonophobia, which are included in the diagnostic criteria, may not be seen, so we can see migraine-type headaches that do not meet the diagnostic criteria in around 10% and headaches that can be called possible migraines in around 45% of children. Another reason that makes diagnosis difficult is that attacks in the form of migraine variants can be seen in children. We should treat migraine attacks that can affect school success, school life, and quality of life after ruling out secondary causes.

Treatment is divided into two as drug and non-drug treatment. Non-drug methods should be tried first in children.

In non-drug treatment;
It is necessary to inform the child and the family about the disease,
Regulating the lifestyle; especially regulation of sleep and nutrition, regular exercise, relaxation techniques and increasing awareness of triggers and ensuring avoidance of them
Rest and sleep in a dark and quiet room when an attack occurs Behavioral therapies; relaxation exercises, biofeedback

Drug treatment is divided into two as attack and preventive treatment.
A number of drugs suitable for age groups are used in acute attacks. Preventive, or prophylactic treatment, can be applied especially to children who prevent daily life activities, create anxiety, and have headaches more than 3-4 days a month. Prophylactic treatment has similar characteristics to those in adults. Side effect profiles and additional disease conditions should be evaluated well in drug selection, and drugs with excessive sleep effects should be avoided, especially in school-age children.

Migraine Treatment in Adolescents
Migraine headaches increase especially in girls during adolescence due to the effect of sex hormones. While it is seen at a frequency of 10% in girls under the age of 12, this rate increases to 18% between the ages of 12-14. In order to determine the relationship between migraine attacks and the menstrual cycle, a headache diary should be kept by the patient for at least two months and a decision should be made and treatment should be started accordingly. All drugs used in adults can be used in acute attacks and treatment.

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HEAD TRAUMA AND BRAIN INJURY

18 Temmuz 2023/0 Yorumlar/in beyin/tarafından drturan_pyrzawp

HEAD TRAUMA AND BRAIN DAMAGE

A healthy brain uses 20% of the blood and energy in our body. The brain is extremely sensitive to being deprived of oxygen and energy. Nerve cells in the brain begin to be damaged and die after 3 minutes. Unfortunately, dead nerve cells cannot be regenerated. However, with the new information we have learned, it is possible to regain the function of damaged cells.

What does brain damage due to head trauma mean?

If you deprive a healthy brain of oxygen, blood flow or energy for any reason, we call the death of nerve cells traumatic brain damage. A sudden traffic accident, sudden blockage of cerebral vessels and damage to the brain are the causes of traumatic brain damage. Pay attention, all the reasons we have listed are sudden causes. In these patients, the brain is damaged quickly and loses its function. Different clinical conditions can be observed in each patient.

The clinical picture seen in patients is primarily related to which part of the brain is affected. I have a patient who was brought to me with serious behavioral disorders such as aggression, forgetfulness, and the frontal lobe of the brain, which we call the prefrontal region, was damaged in a traffic accident. I have a patient who came to me bedridden because the brain area that allows our arms and legs to move was affected. Or I have a patient whose speech suddenly stopped because the speech center in the brain that provides the ability to speak was affected.

I have a patient whose center of consciousness was affected as a result of an electric shock and who was brought to me completely unconscious. All patients’ complaints started recently and suddenly. Is it so important for us doctors that the event started suddenly and is new? Now we are excited about a new development called synaptogenesis-neurogenesis.

Synaptogenesis means that neighboring cells take over the task instead of dead brain cells and the damage in the brain is healed. The event we call synaptogenesis can only be beneficial when we intervene in the patient in the first 1-3 months of the traumatic injury. Therefore, it is important to start treatment in these patients in the first 3 months of the event.

Brain injury treatment due to head trauma

What do we do in treatment? Our main goal is to maximize the capacity of the healthy nerve cell to take over the function of the damaged cell. For this purpose, we perform a three-stage treatment in ensuring synaptogenesis; increasing the blood flow of the brain, strengthening the brain’s energy resources and providing maximum protection to the brain tissue.

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GENERAL BRAIN HEALTH

18 Temmuz 2023/0 Yorumlar/in beyin/tarafından drturan_pyrzawp

1. How does COVID-19 affect the brain?

A number of studies are underway to better understand how and why COVID-19 affects the brain. Early theories so far suggest it happens in two ways. The first mechanism is severe infection that attacks the brain or spinal cord. Some cases reported in China and Japan have found genetic material from the virus in spinal fluid, and one Florida case found viral particles in brain cells. So the virus may actually enter the nose and travel to the brain, causing neurological infection.

The second theory is that the aggressive immune system response to fight the viral infection damages the body and brain. Other effects of the virus, such as fever or organ failure in worst-case scenarios, can also cause brain dysfunction. For example, the immune response damages the lining of blood cells, and blood clots are common in COVID-19 patients. Increased strokes and some neurological complications may be due to this immune system effect on the blood.

2. Are there ways to keep the brain young?
The World Health Organization (WHO) defines healthy aging as follows: Learning, growing, being active, meeting basic needs and socializing, and contributing to society. Protecting brain health is also an important part of ‘healthy aging’.
Nourishing the ‘brain’ as much as the body, benefiting from healthy fatty acids such as Omega-3, doing various exercises for the brain, and continuing to learn and produce are important elements for brain health. Indicators of our brain health are having balanced energy, being able to sleep in good quality, having a sharp memory, good mood and fast learning skills. Therefore, the better we nourish our brain, the more our quality of life increases, and we can even have a young and dynamic brain that produces new nerve cells in old age.

We can examine the answers to what is necessary for brain health under 3 basic questions:

I. Am I aging healthily?

II. Am I consuming brain-friendly foods?
III. Am I exercising my brain enough?

3. Did you know that adult brain cells can regenerate?

Contrary to our old knowledge, we now know that human brain cells can regenerate. If the neurogenesis rate is low during this regeneration process, it causes anxiety, stress and memory problems; if it is high, it increases cognitive abilities and prevents diseases such as dementia and Alzheimer’s. Increasing neurogenesis is not difficult at all. Here is what you can do to increase brain cells. Neurogenesis is the process in which new nerve cells are produced from neural networks. The productive cells in neural networks found in adults have the ability to repair the body and renew adult tissues. Therefore, neurogenesis is perhaps one of the most important biological indicators of brain health. While a low neurogenesis rate can cause anxiety, depression, stress and memory impairment problems, high neurogenesis reduces stress, anxiety and depression, and increases cognitive abilities such as faster learning and better problem solving. It prevents the development of diseases such as dementia and Alzheimer’s. Two factors that increase neurogenesis How can we increase neurogenesis? The two most important factors that have positive effects on neurogenesis are nutrition and exercise. On the other hand, factors such as physical fatigue, rapid aging, sleep problems and stress significantly reduce neurogenesis levels.

4. I don’t have any complaints yet, but what tests can I use to understand if there is a problem with my brain?
It is now possible to create brain maps specific to each person and detect diseases in advance. We definitely recommend this, especially if there is a history of neurological diseases in your family. You may not have any complaints, but you may have a history of Alzheimer’s disease in your family. Your genetic screenings should definitely be done, and your risk ratio should be calculated. If you have a history of stroke, tumor or other diseases in your family, or if you smoke or drink alcohol despite not having any of these, it would be beneficial to be evaluated.

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IT IS POSSIBLE TO INCREASE LEARNING AND BRAIN CAPACITY IN CHILDREN

18 Temmuz 2023/0 Yorumlar/in beyin/tarafından drturan_pyrzawp

Memory and cognitive performance are important requirements for children’s success in both school and social life. However, although it seems like it can be easily solved with regular study, the lessons and exams that the child takes throughout his/her education life are not that easy. Here, a memory called working memory gains importance. Children with a good working memory are more successful in problem solving, planning and organizing tasks and many other points. However, children with working memory problems may have attention deficit and hyperactivity disorder. The good news is that families can increase memory and cognitive performance by applying some strategies.

What is working memory?

First, let’s talk about working memory. We generally know memory as short-term and long-term memory. However, there is also a type called working memory. The type of memory where acquired information is stored but also processed is called working memory. Working memory is very important for children’s academic success. If the child’s working memory is weak, attention deficit and hyperactivity disorder (ADHD) may be seen, but conversely, if the child has attention deficit and hyperactivity disorder, this may lead to a weakening of working memory and cognitive performance.

So how do we do this in children?

1. Increase cognitive stimulation and brain flexibility

The brain development of children between the ages of 3-6, which we call early childhood, is affected by environmental stimuli. The child’s learning ability, experiences, how many stimuli he/she encounters, how many social environments he/she enters, and the socio-economic level of the family affect this development. This fresh brain, which constantly establishes new neural connections, is affected and changes by new information and experiences in the first years of life. This change is actually called brain flexibility, or neuroplasticity. Neuroplasticity is the ability of the nerve cells in our brain to learn and change. This ability allows the acquisition of cognitive functions as well as the determination of motor skills, language skills, social and emotional abilities.

How to increase brain flexibility in children?

One of the most effective ways to stimulate a child’s brain is play. Play is a natural activity that allows the child to learn and relate to their environment. A game is a stimulating activity that requires the functionality of different components of child development, as well as being rewarding in itself.

What does play bring to a child?

Play provides many cognitive gains in addition to the child’s spiritual development. These are;

Reasoning

Stimulation of reflexive (thinking about oneself as an object) and representative thinking and understanding skills

Activation of memory and attention (For example: Hand games, stone games, etc.)

Development of imagination and creativity

Distinction between fantasy and reality

Increasing the development of language and abstract thinking

Development of personal autonomy

With the use of new technologies, various games such as riddles, mazes, and logical problems available for smartphones, computers, and tablets can also improve the child’s cognitive functions. However, games that the child plays with friends or family rather than individually are always more beneficial. If they are going to play individually, games that require imagination provide this flexibility and cognitive gain. If we consider toys, toys that offer all functions are not useful, but toys that allow children to do different things with their imagination, such as Lego or plain, not too colorful wooden blocks. In addition to these, games such as puzzles that require putting the pieces together provide the same benefit. In addition to toys, we have known for a long time the positive effect of playing a musical instrument on intelligence. Research shows that children who are involved in music have significantly more academic success than others.

2. Don’t skip physical exercise

We know that physical exercise has many benefits for the brain and keeps the brain sharp. Physical exercise does this both through the hormones and chemicals it secretes and by improving brain-hand coordination and motor skills. In addition, oxygen to the brain also increases. Thanks to exercise, the level of the hormone we call BDNF, known as the growth hormone, also increases and this initiates neuroplasticity by enabling the formation of new nerve connections. Directing children to exercises that will both challenge them and that they will enjoy, such as skating, skateboarding, and cycling, can be beneficial in this respect. Since children have much more energy than us, getting tired does not make it difficult for them to focus on the lesson. This situation creates an opportunity for their brains to develop and increase their learning capacity.

3. Pay attention to sleep

Sleep allows the information learned during the day to be processed and transformed into permanent information. Sleep deprivation directly negatively affects memory, creativity, problem solving and critical thinking skills. It also increases aggression, restlessness and hyperactivity in children. It is thought that children who do not sleep well do not sleep because they are hyperactive, but most often it is the opposite; children who do not sleep well are cranky, hyperactive and overactive. Therefore, sleep directly affects learning and school success. In order for your children to get enough sleep; Put them to bed at the same time and wake them up at the same time every day. Do not break the routine even on weekends and holidays. Let them stay away from all technological devices at least 3 hours before going to bed. Prevent them from eating too much sugar and carbohydrates.

4. Ensure that they socialize

Socialization and communicating with many people gives the child the opportunity to observe. This is something that develops the child’s intelligence. An isolated life and only living within the family is a great disadvantage for the child because social activities also stimulate our brains. Researchers from Harvard University discovered that people with the most active social life have the lowest rate of memory decline. Socialization, especially for children, provides memory-enhancing benefits. Therefore, it is better for them to be with their social circle even while having fun and playing games. Especially in children who become individualized with technology and lock themselves in their rooms, serious cognitive and emotional problems occur.

5. Pay attention to your diet for brain health

You need to fuel your brain with the best fuel. A diet based on fruits, vegetables, whole grains, “healthy” fats (such as olive oil, nuts, fish) and protein also improves memory. We know that omega-3 fatty acids are essential for brain health and have a positive effect on memory. Oily fish found in cold waters such as salmon, tuna, halibut, trout, mackerel, sardines and herring are also very rich sources of omega-3. In addition, omega-3 sources such as walnuts, flaxseed, pumpkin, kidney beans, spinach, broccoli and pumpkin seeds, which grow abundantly in our soil, can be alternatives for children who do not like fish. Supplements rich in DHA and EPA, which are found in omega-3 fatty acids, can also be beneficial for brain health. You can also ensure that your child takes food supplements containing these.

Fruits and vegetables are full of antioxidants that protect us from toxins and the damage they cause. Especially colorful fruits and vegetables are good sources of antioxidants. You can make sure that your child’s plate contains fruits and vegetables of various colors such as red, green, and yellow. Consuming too many carbohydrates, especially processed carbohydrates containing white flour, can damage memory. In addition, these foods with a high glycemic index, which cause blood sugar to rise quickly and then drop quickly, cause your child to be sleepy, low in energy, and have trouble focusing. Research also confirms this. A diet full of refined carbohydrates causes a decline in memory and cognitive functions. A study conducted on 317 healthy children found that those who consumed more processed carbohydrates such as white rice, noodles, and fast food had reduced cognitive capacities, including short-term memory and working memory. Eating too much sugar causes the part of the brain that stores short-term memory in particular to weaken and decrease in volume. Therefore, it is important to reduce sugar. However, this does not only help memory, it also improves general health. In fact, it is not enough for children to just avoid sugar. The hippocampus, the memory-related part of babies born to mothers with high blood sugar during pregnancy, does not develop normally. These babies may have worse memory than babies of the same age.

Vitamin D plays many vital roles in the body, as well as being important for brain health and cognitive capacity. Low levels of vitamin D are linked to decreased cognitive function. One study found that those with insufficient levels of vitamin D in their blood had decreased memory and other cognitive abilities. Vitamin D deficiency is especially common in colder climates and those with darker skin. You can find out if your child needs a vitamin D supplement by getting a blood test.

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IS BRAIN REGENERATION POSSIBLE ?

18 Temmuz 2023/0 Yorumlar/in beyin/tarafından drturan_pyrzawp

Brain cells can renew, can we all do this?

There are connection paths between nerve cells in the brain and thanks to these paths, all cells communicate and chat with each other. When new information enters the brain or the brain is exposed to an environmental threat, neighboring nerve cells communicate with each other, produce solutions and manage the process together. We call this situation, which helps us adapt to all external events, brain flexibility. The words brain flexibility and neuroplasticity are composed of the words neuron; nerve cell and plasticity; malleable. Brain flexibility is not only when injuries heal, but also reacts to all environmental factors in the outside world and undergoes changes. You can increase neuroplasticity and format your brain by opening yourself to new experiences. You should make a conscious effort to format your brain, if you add passion and enthusiasm to this, it will be great.
Never underestimate your brain. With neuroplasticity, the brain can turn into an incredibly adaptable and renewable organ. Stop complaining that I have forgetfulness and my memory is not as strong as it used to be and format your brain with neuroplasticity.

What are the Principles of Brain Flexibility?
1. “Use or Lose”
Neural connections that are not actively continuing the task are deactivated in order not to take up space. Therefore, repetition is important to achieve success in the task given to the brain. For example, if you are eager to learn a new language and do not repeat what you have learned frequently, you will forget it after a while.
2. “Use and Improve”
Continuous triggering of a specific brain function allows that function to develop further. If a stroke patient who cannot use one side of his body tries to move the arm or leg on the side he cannot use as much as possible, the area of ​​the brain that controls this will develop faster.
3. “Repetition is Important”
A sufficient level of repetition is necessary to ensure flexibility. One of the difficulties that therapists face in the rehabilitation environment is often not being able to clearly determine how much time is needed for the patient to acquire certain skills. For example, in a case where a patient has to learn to walk again, it is important for him to try to walk not only when he sees the physiotherapist, but also at other times in order to achieve this.
4. “Intensity is Important”
Creating flexibility requires intensive therapy. This is also related to the concept of repetition. If we return to the example of a stroke patient who cannot use one side of his body, questions such as “What is the appropriate dose of therapy? How many sessions would be sufficient? How long should these sessions last?” are frequently encountered. The more intensive the therapy, the faster the increase in brain functions and therefore physical and cognitive abilities.

5. “Time is Important”
After an injury, the brain wants to heal as quickly as possible, if it is delayed and the treatment period is extended, more time must be spent to create change. In other words, the earlier you intervene in an affected brain, the greater your chance of success.

6. “Awareness is Important”
In creating flexibility, it is important for the patient to know how and why they should do the exercises. Because the awareness of the patients about their condition and exercises also affects the recovery process. The therapist needs to know what is important to the patient. Emotions definitely have the potential to increase the power of therapy, for example, when the patient is aware of their condition and wants to participate in their exercises, it makes the brain want to heal more, and keeps the changes in the memory more permanent.

7. “Age Matters”
Stimulating flexibility is easier in young brains. Younger brains can adapt to changes much more easily than older brains.

So, what should we do?

1. Take a brisk walk outdoors at least 3 days a week for at least 30 minutes. The most important method for increasing brain flexibility is physical activity. It is known that exercise increases ‘neurotrophic factors’ that contribute to brain development and stimulates angiogenesis, which enables the formation of new blood vessels.

2. Be mentally active. Watch the news, solve puzzles, learn new things such as a new language. Mental exercise increases ‘Brain-Derived Neurotrophic Factor’, which is important for the brain, and synaptogenesis, which establishes connections between nerve cells.

3. Stress is a factor that reduces flexibility, stay away from stress. Try to take as much responsibility as you can. Stress negatively affects our memory skills. When you feel really stressed, you easily forget where you put your keys or other daily things. High levels of stress hormones for a certain period of time can reduce the connections between nerve cells and make it difficult to create new information.

4. Maintain your social relationships and activities. Reading books, taking up hobbies, continuing to do your routine work, socializing by going to places where you are invited and meeting with friends and relatives will increase synaptogenesis, which establishes new connections in the brain. 5. Eat well. Neuroplasticity can be improved with a balanced diet rich in content and containing every nutrient. We should care about our nutrition at every stage of life and should not forget that our diet content is the most important key to a long and healthy life.

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WHAT IS STROKE ? CAN IT BE PREVENTED ?

18 Temmuz 2023/0 Yorumlar/in beyin/tarafından drturan_pyrzawp

What is stroke?

The clot that goes to the brain does not only come from the heart, but also the brain veins age as we age, and a process called arteriosclerosis occurs. This can create clots on the veins, and these clots go to the brain. Let’s think of the main vein coming out of the heart as a tree root. Let the end branches of the tree be small veins, and clots can come out of the root and cause blockages on the way. If the branches are blocked, the brain’s nutrition is disrupted, if the small vein is blocked, it causes less damage, and if the large vein is blocked, it causes more serious damage. These vein branches coming out of the heart narrow as they go deeper into the brain. The larger the clot, the earlier it blocks the vein and the more damage it causes. Stroke is a condition that occurs suddenly and results in loss of brain functions.

Stroke/paralysis in our country

Approximately 200,000 people have a stroke in our country every year. Every 40 seconds, one person has a stroke; and one person loses their life due to stroke in three minutes. Stroke was the third leading cause of death on the World Health Organization list until the last 20 years. However, especially in the last 20 years, thanks to rapid developments in diagnosis and treatment, it is a treatable disease and early action is vital for this treatment to be successful. In emergency cases, centers with experience in stroke should be determined for rapid and successful treatment and the emergency service should transport patients to these centers. Stroke treatment is a personalized treatment due to both the good evaluation of the process and the fact that the treatment methods to be used vary from patient to patient. In the fight against stroke, it is important not to have a single physician but a competent multidisciplinary team. There are diseases in medicine where we race against time, stroke is one of these diseases. We say that every passing time is the brain because the longer we delay reaching the health center as time goes by, we lose a part of our brain, stroke is such a disease. When we say stroke, it is considered distant from us but it can be very close to you. It can happen to anyone at any time. We are not disabled today but we can be tomorrow. Especially people in the risk group are important.

CAN STROKE BE PREVENTED?

Approximately 200,000 people have a stroke in our country every year. One person has a stroke every 40 seconds, and one person dies of a stroke every three minutes. Until the last 20 years, stroke was ranked 3rd among the causes of death on the World Health Organization list. However, especially in the last 20 years, it has become a treatable disease thanks to rapid developments in diagnosis and treatment. Therefore, acting early is vital for the treatment to be successful.
In emergency cases, centers experienced in stroke should be determined for fast and successful treatment and the emergency service should transport patients to these centers. Stroke treatment is a personalized treatment due to both the good evaluation of the process and the fact that the treatment methods to be used vary from patient to patient. In the fight against stroke, not a single physician but a multidisciplinary, competent team is of great importance…

There are diseases in medicine where we race against time. Stroke is one of these diseases… We say that every passing time is the brain because as time goes by, the more we delay reaching the health center, the more we lose a part of our brain, stroke is such a disease. It seems distant from us, but it can be very close to you. It can happen to anyone at any time. We are not disabled today, but we may be tomorrow. Especially people in the risk group are very important in this respect…

STROKE GIVES INFORMATION IN ADVANCE

Stroke often gives in advance that it will come. Preventive treatment of people at risk before a stroke develops should be the most important approach. Among the lifestyle changes in preventing stroke, nutrition is especially important. Avoiding foods containing saturated fatty acids and simple carbohydrates, taking care to eat fiber-rich foods, eating a diet rich in fruits and vegetables, and limiting salt are important. It has been shown that the Mediterranean diet is especially protective against stroke (a diet containing olive oil and vegetables).

On the other hand, increasing physical activity and doing aerobic exercises outdoors without straining are associated with a decrease in the risk of stroke. It is recommended that individuals regularly practice outdoor walking exercises for 45 minutes-1 hour 4 days a week or at least 30 minutes a day.

It is important to control risk factors such as hypertension, diabetes, high cholesterol, keep blood pressure below 140/90 mmHg, completely stop smoking and limit alcohol consumption, and reduce excess weight to appropriate limits with diets. Regular use of medications recommended by your doctor for these risk factors reduces the risk of stroke.

8 simple changes to reduce your risk of stroke:

Be active.
Keep your cholesterol under control.
Eat healthier.
Keep your blood pressure under control.
Lose weight.
Lower your blood sugar.
Quit smoking.
Reduce alcohol.

Even one of these is effective, but controlling all of them has been shown to significantly reduce the risk of stroke. So the more changes you make, the more your risk drops. For example, lowering your blood pressure to normal levels reduces your risk of stroke by 50 percent. Not smoking or quitting smoking reduces the risk by 40 percent.

EMERGENCY STROKE TREATMENT

Since it is generally not known whether stroke can be treated, it is very late to take patients to the hospital. There is a lack of information about the treatment of this disease. Unfortunately, there is a prejudice in society that ‘stroke cannot be treated’.

However, today, if a patient who has a stroke is taken to the hospital in the first hours and the sooner that patient is treated, the chance of treatment increases. It seems much easier for patients to return to their social life even if they have a stroke. Our society is not yet aware of this treatment, we need to increase awareness of this treatment.
Stroke treatment is a new approach in terms of intervention, it is necessary to save the brain tissue that is sensitive to lack of oxygen after the formation of the clot and to prevent the damage that will occur. Every minute that passes after a stroke means millions of cell deaths. Clot-dissolving treatments via veins must be applied to the patient in the first 4.5 hours of the stroke, and the method of removing the clot in the vein by performing cerebral angiography, i.e. mechanical clot removal, must be applied to the patient in the first 8 hours. When the treatment is applied within the first 3 hours, 1 out of 7 patients recover completely, when it is applied within the first 4.5 hours, 1 out of 11 patients recover completely.

SHOULD WE USE ASPIRIN IN CASE OF A SUDDEN STROKE?
The cause of a stroke may be a brain hemorrhage or a vascular occlusion. When we give a blood thinner, we may increase the bleeding. Therefore, we should not take a blood thinner drug on our own.

SHOULD WE MEASURE BLOOD PRESSURE IN STROKE AND GIVE BLOOD PRESSURE MEDICATION?

There is definitely no need to give a drug to lower blood pressure if such a patient has high blood pressure. The main problem here is that stroke mostly develops in those with high blood pressure, but if the blood pressure is high when we have a stroke, it should not be lowered because a vein is blocked and the vein carries blood to the brain. If we give medication for blood pressure, the blood pressure drops and the blood flowing to the brain decreases. In case of a sudden stroke, blood pressure medication should not be given.

SHOULD WE POUR COLOGNE ON THE PATIENT?

Giving the patient water, pouring cologne on them seem like things done to bring the patient back to his senses, but in fact, these waste doctors’ time. They steal time, but we need to act quickly, and time is limited for what we can do in the emergency room. We need to get the patient to the emergency room as soon as possible. When the patient has a stroke, their swallowing function may have been impaired. Therefore, we should not feed them or give them water to drink, otherwise it can get into the lungs and cause pneumonia, causing the disease to worsen rapidly.

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OTHER NON-DRUG TREATMENT METHODS

18 Temmuz 2023/0 Yorumlar/in Genel/tarafından drturan_pyrzawp

These treatments are not specific to migraine, but can also be used in various types of headaches. Although there is not enough evidence for some of these methods, they can be used in some well-selected patients.

Trigger point injection

Trigger point treatment is a treatment method that can be used in different types of headaches, especially migraine and tension-type headache. The condition referred to as a trigger point is the formation of an inflammatory reaction due to the involuntary contraction of a group of muscle fibers for a long time for various reasons, and this chronic inflammatory condition causes an increase in the release of pain neurochemicals, especially CGRP and Substance P. A number of local anesthetics, physiological serum, cortisone or Botox can be used for these pain centers, as well as the intramuscular stimulation method of thin and specially produced needles known as dry needles.

Dry needle treatment

This is an effective application based on the application of thin and specially produced needles to these tense muscle groups with the intramuscular stimulation method. As the name suggests, any drug is used in this application. Its effectiveness has been supported by many scientific studies. Since it does not involve the use of medication, it is especially preferred in restrictive situations such as drug intolerance, allergy or pregnancy.

Acupuncture

Based on traditional Chinese medicine and used in the treatment of many diseases today, acupuncture is thought to be effective especially in migraine attack periods. It is based on the principle of reducing pain by inserting needles of various characteristics into certain points.

Migraine surgery

It is based on the principle of releasing the muscles and veins around the nerve branches in the areas of the brain associated with migraine, especially the trigeminal nerve branches. This method, which is not included in migraine treatment guidelines, may cause some nerve-based pain due to the irreversible/permanent neuroanatomical deterioration it will create, and may also trigger migraine headaches. There are safer, cheaper treatments with fewer side effects compared to this invasive procedure.

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NEUROMODULATION

18 Temmuz 2023/0 Yorumlar/in Genel/tarafından drturan_pyrzawp

Neuromodulation is the concept of stimulating and reorganizing nerve tissues that cause neurological diseases, have lost function, or cause various clinical symptoms due to dysfunction, through chemical or electrical applications. Providing stimulation in nerve tissues that have lost function can partially restore the missing function of this nerve tissue. With this method, abnormal stimuli and/or pain caused by nerve tissue can be suppressed with neuromodulation and the patient’s complaints can be reduced.

How does neuromodulation show its effect?

In nerve tissues that have suffered functional loss, a number of neurochemical substances are released and various abnormal electrical activities occur through these neurochemical substances. In a healthy nerve tissue, the nerve continues its physiological function with the type and help of these neurochemicals. Due to the damage to the nerve tissue and the functional loss that occurs as a result, physiological electrical activity may not be provided. In this respect, the electrical and chemical stimulation given to the patient from outside with neuromodulation provides the reorganization of these mechanisms.

For this stimulation, batteries that can generate electricity from outside or pumps that inject drugs help. These batteries used for neuromodulation are applied by placing electrodes into the tissue in a way that fits the nerve tissues in the brain, spinal cord or body areas close to these regions. These electrodes produce electrical impulses with an appropriate intensity to stimulate the targeted tissues. Problems related to many different neurological diseases such as Parkinson’s disease, essential tremor (tremor disease) and migraine can be solved with these methods.

What are the diseases in which neuromodulation is used?

Neuromodulation can be used in the treatment of any neurological disease that causes deterioration in the functions of nerve cells. Since neuromodulation equipment must be placed inside the body with interventional methods in patients and it is an expensive method, its application is usually brought to the agenda in clinical cases that are resistant to drug treatment, not suitable for surgical treatment and accompanied by severe clinical symptoms.

The most common disorders in which neuromodulation is used in clinical applications are epilepsy, migraine, chronic nerve-related pain, Parkinson’s disease, urinary incontinence and hearing loss. Neuromodulation treatment methods that are successfully applied today can be listed as follows:

  • Spinal cord stimulation (spinal cord pacemaker)
  • Posterior root ganglion stimulation
  • Sacral nerve root stimulation (bladder pacemaker)
  • Chronic pain neuromodulation
  • Peripheral nerve stimulation
  • Deep brain stimulation (brain pacemaker)
  • Intrathecal drug infusion (baclofen pump)
  • Vagal nerve stimulation (epilepsy pacemaker)
  • Transcutaneous electrical nerve stimulation
  • Transcranial magnetic stimulation
  • Cochlear nerve stimulation
  • Visual prosthesis

What are the concepts of neuromodulation and neurostimulation in migraine treatment?

Neuromodulation (NM) and neurostimulation (NS) have an important place among non-drug treatment options for migraine. Classic drug treatments are the first line in migraine treatment. The answer to the question of which migraine patients are subject to non-drug treatments is;

Patients whose attacks continue despite receiving appropriate drug treatment,

Patients who experience side effects due to the drugs used,

Patients who have interactions between drugs used for migraine treatment due to another disease,

Patients who have another medical condition that prevents them from taking appropriate drugs.

NM and NS have become important methods among non-drug treatment options for migraine.

How do neuromodulation and neurostimulation affect migraine?

The neurostimulation method can be briefly defined as the stimulation of loss of function or abnormal neurochemical response in the nerves associated with headache by means of an electrical current, magnetic current or direct current with the help of specially developed devices.

NS in migraine can be performed on the skin around the head, or with special devices placed invasively near the nerves that cause headaches.

Non-invasive methods applied on the skin around the head;

Supraorbital Transcutaneous Stimulation (STS)

Transcranial Magnetic Stimulation (TMS)

Transcranial Pulse Stimulation (TPS)

Transcranial Direct Current Stimulation (TDAU)

Vagal Nerve Stimulation (VSS)

Each of these methods may not be suitable for every migraine patient. Therefore, it should be determined which of these methods will be used selectively for patients whose appropriate indications have been determined by a neurologist.

Supraorbital Transcutaneous Stimulation (STS)

Cefaly

It is applied to the supraorbital nerve, which is also used for nerve blockade. It originates anatomically from the eye socket and is known to be associated with headaches. The device is attached to the head like a band or crown and provides electrical stimulation to the supraorbital nerve with certain frequencies.

The application practice is in the form of 20-minute stimulations per day for 3 months.

The first STS device approved by the American Food and Drug Administration (FDA) for chronic migraine was offered to patients under the name Cefaly᷿®. This device for chronic migraine was approved for prescription only, but later it was approved for over-the-counter sales.

This wearable migraine device has been updated as Cefaly Dual with the latest technological innovations and was approved by the FDA in 2020 for the acute (attack period) and preventive treatment of migraine headaches in adults aged 18 and over.

The device (Cefaly Dual) has 2 settings; ACUTE and PREVENT

In the ACUTE setting, the device is used for 60 minutes of pain relief at the beginning or during a migraine attack.

The PREVENT setting reduces the frequency and intensity of migraine symptoms in 20-minute sessions per day. The device automatically turns off at the end of each session.

Relivion MG

Another e-TNS device is Relivion. Unlike Cefaly, this latest noninvasive device delivers electrical stimulation to both the trigeminal nerve branches and the occipital nerve branches (stimulating a total of 6 nerve branches). It has two sensors placed on either side of the nose. It was approved by the FDA in 2021 for the treatment of acute migraine in adults. It is in the device group that requires a doctor’s prescription.

Transcranial Magnetic Stimulation (TMS)

As its name suggests, it is a device that shows its effect by giving magnetic stimulation to certain brain regions. This device, which is more known among migraine patients, is thought to affect the release of certain neurochemicals by giving magnetic stimulation from the back of the head, known as the occipital region, with the help of an apparatus that we can call a stimulator, by affecting the electrical fields in the cerebral cortex. It is thought to achieve this effect by affecting the polarization in the nerve tissue.

The TMS device was approved by the FDA in 2013 for migraine patients aged 18 and over, only for migraine attacks with aura.

Having metal in the head, neck or upper body, having an active implanted medical device (pacemaker, deep brain stimulator etc.), having a diagnosis of epilepsy, having a history of seizures in the family or in oneself are contraindications for TMS.

As a rule, it should not be applied more than once in 24 hours.

Single-pulse TMS (sTMS)

A potential preventive and acute treatment for migraines, sTMS can be applied at home by placing and activating a device behind your head. The device delivers a short magnetic pulse (the length is preset by your doctor) that targets the layers of the scalp, skull, meninges (membranes surrounding the brain and spinal cord), cerebrospinal fluid, and superficial layers of the cortex, where it modulates the electrical environment of neurons involved in migraine attacks.

In a study published in the journal Cephalalgia in May 2018, sTMS reduced the number of days people with migraines experienced symptoms. Users also needed less rescue medication.

The eNeura sTMS mini is an FDA-approved sTMS device, previously sold under the brand name Spring TMS. Battery-powered and handheld, it can be used for both prevention and treatment of migraine attacks.

The user places and holds the sTMS mini firmly against the back of the head to locate the base of the skull. With the push of a button, the device’s specially shaped electrical coils send a magnetic pulse designed to treat migraine attacks and prevent them by interrupting the abnormal electrical activity in the brain that is associated with them.

You need a doctor’s prescription to use the sTMS mini.

Transcranial Pulse Stimulation

The device on the market under the name Neurolith® has a mechanotransduction mechanism. Although it is mainly used for Alzheimer’s disease (by increasing growth factors, VEGF, cerebral blood flow, new vessel formation, nerve regeneration and nitric oxide release), studies are also ongoing for the treatment of migraine.

Vagal Nerve Stimulation (VSS)

Noninvasive VSS is thought to be effective in the treatment and prevention of migraine and cluster headache with the help of special devices such as the gammaCore® (electroCore) device. After being approved for the acute attack period of migraine in 2015, it was also licensed for the treatment of cluster headache in 2019.

The device has also been licensed for the acute and preventive treatment of migraine and cluster headaches for ages 12-17 as of February 2021. The device, which is the size of a computer mouse, applies a lubricating gel to the two stimulation points and then electrically stimulates the patient under the jawline, from any neck area for approximately 2 minutes. The intensity of the stimulation can be adjusted by the patient themselves. Regular use twice a day is recommended as a preventive treatment (for 3 months). It is the only NS device that has been approved for the treatment of hemicrania continua and paroxysmal hemicrania. A doctor’s prescription is required.

REN/Remote Electrical Neuromodulation

Remote electrical neuromodulation (REN) may be particularly useful for people with migraines who are concerned that using devices that apply electrical stimulation to the head may worsen the pain associated with attacks. Uniquely, this approach is designed to stimulate peripheral nerves in the upper arm. It is thought to reduce migraine pain by modulating a deep part of the nervous system involved in pain control. Specifically, REN activates pain control centers in the brainstem (the connection between the brain and spinal cord), which in turn blocks the pain signal that occurs in migraines.

Nerivio

Nerivio is a wireless remote neuromodulation armband that is FDA-approved for the acute treatment of migraine with or without aura in people ages 12 and older. The device is controlled by an app designed to provide personalized treatments.

The app includes a migraine diary that allows you to track treatment sessions and migraine attacks. You can share the diary with your doctor to help guide your migraine management.

Nerivio is available only with a doctor’s prescription.

Each Nerivio device provides twelve 45-minute treatments. After 12 treatments, the battery no longer works and the device must be recycled.

Implantable Occipital Nerve Stimulation

Implantable occipital nerve stimulation involves surgically implanting a device that sends electrical pulses to the occipital nerve, which is located at the back of the head, just above the neck. It is primarily used for chronic migraine patients who have failed other treatments.

A study published in the December 2020 issue of the journal Pain and Therapy found that the approach was effective for about 50 percent of people with chronic migraines who had an ONS device implanted.

ONS, in particular, differs from other nerve stimulation systems in that it involves surgery, but the procedure is reversible.

An implantable device under development by Salvia Bioelectronics uses mild electrical impulses to affect nerve activity, or the pattern of electrical impulses transmitted through the nerve fibers that control how your body works. The Dutch company is working on thin implantable bioelectronic foils that conform to the shape of your head to provide neurostimulation.

Specifically, the company’s implantable neurostimulation system (similar to a pacemaker) will be designed to use bioelectronic foil technology to disrupt brain processes that cause migraine attacks in people who have failed drug therapy. In 2020, the FDA granted Salvia a breakthrough device designation for its implantable technology.

  1. GammaCore
  2. NERİVİO
  3. CEFALY DUAL
  4. eNeura S-TMS mini
  5. RELİVİON

 

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BOTULINUM TOXIN TREATMENT

18 Temmuz 2023/0 Yorumlar/in Genel/tarafından drturan_pyrzawp

Botulinum toxin or Neurotoxin treatment has been frequently mentioned in neurology practice in recent years, especially in migraine treatment.

Botulinum Neurotoxin (BoNT) is actually a very powerful poison produced from a bacterium. What makes this poison a medicine is knowing the dose and the fact that the practitioner is a physician.

BoNT, which has been used for many years and was first used in the treatment of strabismus and blepharospasm, was last approved by the US Food and Drug Administration (FDA) for migraine treatment after the PREEMPT study published in 2010. The PREEMPT study showed that BoNT reduces the frequency and severity of migraine pain, reduces the rate of painkiller use, and increases the quality of life. Therefore, it has been supported that it is also effective in medication overuse headaches.

Who can BoNT be applied to in migraine?

The indication is for CHRONIC MIGRAINE patients diagnosed by a neurologist. The criteria here are quite clear;

It is applied to patients who experience migraine pain 15 or more days a month,

Those who have used other migraine prophylaxis medications,

Over the age of 16, and are not pregnant.

How and by whom is it done?

The procedure is performed on standardized forehead, temple, neck, nape and shoulder points with specially manufactured injectors. The procedure should be performed on at least 31 points and a total of 155 Units. In some resistant cases, additional trigger points can also be applied. The maximum application dose is determined as 195 Units.

The procedure should be performed by a NEUROLOGY specialist. The procedure is completed in approximately 10-20 minutes, excluding the preparation process.

Is there any pain during the procedure?

Since very fine-tipped injectors are used for the procedure and some applications can be made before the procedure to reduce the feeling of pain, there is no significant problem other than a slight feeling of pain.

Where should the procedure be performed?

It should not be performed outside a health institution/clinical environment. In order to ensure hygiene and asepsis rules during the procedure and to monitor any problems that may arise related to the procedure, the procedure should be performed under the supervision of a NEUROLOGY specialist with experience. BoNT application in migraine is part of a holistic approach to migraine treatment and is a medical treatment. It is not a cosmetic application. It should be performed by neurologists who are technically appropriate, can monitor pain, and are specialized in this field.

What is the frequency of application?

The application is repeated 3 months after the first application and then every 6 months for at least 2 years. In order to evaluate the success of the application, it must be done at least twice. It cannot be said that this treatment is not beneficial without at least two applications.

What are the expected effects?

The main goals are to reduce the frequency of migraine attacks, shorten their duration and alleviate their severity. However, a decrease in excessive painkiller use is also expected. As a result of all this, there is an increase in the quality of life due to migraine, which is one of the most important workforce losses under the age of 50.

Does it have any side effects?

It has very few side effects and is easily tolerated. BoNT is a reliable treatment for migraine. The important point is to perform the procedure with the right technique and at appropriate doses. Despite all this, temporary neck pain, sometimes headache, weakness in the neck muscles, drooping eyelids, pain and redness at the injection sites may occur. These side effects are temporary and rarely seen.

How does botulinum neurotoxin relieve migraine pain?

BoNT, in cases of dystonia, spasticity, hemifacial spasm or blepharospasm, which can be summarized as excessive and involuntary muscle contractions seen in neurology practice, causes a soft and temporary paralysis in the muscles and temporarily prevents muscle contraction. This effect lasts for an average of 6 months.

In migraine attacks, the mechanism of action is different. The applied BoNT technically affects the nerve ending points located in the forehead, temples, nape and neck. BoNT applied to these points enters the nerve endings and suppresses the release and production of certain neurochemical substances (CGRP, Substance P etc.) that carry the sensation of pain to the pain centers of the brain. BoNT, which also affects the pain receptors (receptors) located in these nerves and that have become easily sensitive to stimulation by certain migraine triggers, helps to eliminate attacks related to triggers by preventing this sensitization (desensitization).

How long does botulinum toxin treatment last? Is it lifelong?

BoNT, in neurological diseases that cause excessive and involuntary muscle contractions such as dystonia, spasticity, hemifacial spasm or blepharospasm, its effect of preventing muscle contraction lasts for an average of 6 months. At the end of this period, it may be necessary to apply it again depending on the condition of the complaints.

In migraine, the mechanism of the neurotoxin is different, it affects the nerve cells in the brain regions that cause migraine, reduces the release of neurochemicals that cause pain production and especially the desensitization effect on the pain receptors in the nerve endings, leading to pain control. The general acceptance in migraine is to continue the treatment for up to 2 years with applications repeated 3 months after the first application and every 6 months. However, after 2 years, it may be necessary to repeat the application at certain intervals depending on the clinical condition of the patient and the neurologist who monitors the patient.

https://drturanpoyraz.com/en/wp-content/uploads/2023/07/botulinum.jpg 665 1000 drturan_pyrzawp https://localveri.net/drturanpoyraz/wp-content/uploads/2024/07/logo2.png drturan_pyrzawp2023-07-18 15:36:542024-08-01 16:33:30BOTULINUM TOXIN TREATMENT
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